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    The value 'Show more Show more Revision: v2.9.0' has been updated to 'Show less MedlinePlus Genetics related topics: Attention-deficit/hyperactivity disorder Drug Information available for: Lisdexamfetamine Lisdexamfetamine dimesylate FDA Drug and Device Resources Show less Design Details Primary Purpose : Treatment Allocation : Randomized Interventional Model : Parallel Assignment Masking : Double ( Participant Investigator ) Arms and Interventions Participant Group/Arm Intervention/Treatment Active Comparator : Vyvanse Patients may be randomized to the active comparator arm. Participants randomized to this arm will receive 30, 50, or 70mg Vyvanse daily. Drug : Vyvanse Vyvanse 30, 50, or 70 mg daily Other Names: Lisdexamfetamine Placebo Comparator : Placebo Patients may be randomized to the placebo comparator arm. Those randomized to this arm will receive 30, 50, or 70mg placebo daily. Drug : Placebo Placebo 30, 50, 70 mg daily Primary Outcome Measures Outcome Measure Measure Description Time Frame Participants Experiencing Collisions During 'Surprise Events' in Driving Simulator Initial results from a one hour driving simulation in the MIT AgeLab Driving Simulator as compared to second session in the simulator following a 6-week trial on Lisdexamfetamine or placebo. During the simulation, 'surprise events,' designed to test the participant's attention and driving, occurred. This outcome presents the difference in number of collisions experience by individuals treated with Vyvanse or Placebo. 6 weeks Keywords Provided by Joseph Biederman, MD, Massachusetts General Hospital ADHD young adults driving Vyvanse lisdexamfetamine Additional Relevant MeSH Terms Attention Deficit and Disruptive Behavior Disorders Neurodevelopmental Disorders Mental Disorders Attention Deficit Disorder with Hyperactivity Central Nervous System Stimulants Physiological Effects of Drugs Dopamine Uptake Inhibitors Neurotransmitter Uptake Inhibitors Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action Dopamine Agents Neurotransmitter Agents Lisdexamfetamine Dimesylate Revision: v2.9.1.'
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