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    The page has undergone significant content changes, including the removal of detailed study descriptions and criteria for a clinical trial on advanced melanoma, while adding a new version revision and a reference to malignant melanoma.
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    The page has removed a notice regarding heavy traffic affecting the performance and availability of some NLM-NCBI services and products.
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    The web page now includes a notice about heavy traffic affecting the performance and availability of some NLM-NCBI services and products, along with contact information for assistance.
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