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Latest updates to the ORION-3 Extension Trial: Inclisiran in Cardiovascular Disease Clinical Trial page

  1. Check
    3 days ago
    No Change Detected
  2. Check
    10 days ago
    No Change Detected
  3. Check
    17 days ago
    Change Detected
    Summary
    Key results data and descriptions were removed from the Study Results page, including participant counts by timepoint and arm, and several primary/secondary outcomes (LDL-C, PCSK9, triglycerides, ApoB) along with adverse events.
    Difference
    0.9%
    Check dated 2026-04-01T02:53:26.000Z thumbnail image
  4. Check
    25 days ago
    Change Detected
    Summary
    Revision label updated from v3.4.3 to v3.5.0; this appears to be a versioning change rather than substantive content updates.
    Difference
    0.0%
    Check dated 2026-03-24T20:44:12.000Z thumbnail image
  5. Check
    33 days ago
    Change Detected
    Summary
    Revision tag updated from v3.4.2 to v3.4.3 on the page.
    Difference
    0.0%
    Check dated 2026-03-16T18:25:01.000Z thumbnail image
  6. Check
    66 days ago
    Change Detected
    Summary
    Revision: v3.4.2 is added and updated results sections include Absolute Change in PCSK9 Levels From Baseline for ORION-3 at Days 30, 360, 720 and 1440 with corresponding participants. LDL-C and related outcome data points have been updated or clarified, and arm descriptions/timeframes are explained.
    Difference
    0.2%
    Check dated 2026-02-11T02:40:06.000Z thumbnail image
  7. Check
    74 days ago
    Change Detected
    Summary
    New results data were added, including Mean (95% CI) values, units (ug/L), and timepoint-specific LDL-C and PCSK9 changes with participant counts. A government funding notice regarding potential delays and the NIH Clinical Center's status was also added.
    Difference
    0.2%
    Check dated 2026-02-03T23:48:08.000Z thumbnail image
  8. Check
    81 days ago
    Change Detected
    Summary
    Glossary display was added and QC-related notes were introduced. Several data rows and numeric summaries in the results tables were removed, reducing the amount of visible results data.
    Difference
    0.2%
    Check dated 2026-01-27T21:07:27.000Z thumbnail image

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